Hydroxyethylamide substituted triterpenoic acids hold good cytotoxicity for human tumor cells

Producing Soluble Human Programmed Cell Death Protein-1: A Natural supporter for CD4+T cell Cytotoxicity and Tumor Cells Apoptosis

Background: Programmed cell death protein-1 (PD-1)/PD-L1 pathway is one of the immune checkpoint pathways involved in regulation of the immune responses and suppression of anti-tumor defense. PD-1/B7-H1-blocking antibodies improve immune responses such as cytotoxic activity of CD8+/CD4+T cells and also increase mortality of tumor cells; however their use is accompanied by adverse effects in pat...

Human monocyte antibody-dependent cell-mediated cytotoxicity to tumor cells.

Previous investigations of mononuclear cell antibody-dependent cell-mediated cytotoxicity (ADCC) toward tumor cells suggest that K lymphocytes and not monocytes are active in this cytotoxic reaction. This report, however, demonstrates that human monocytes are able to carry out ADCC toward three different human tumor cell lines (CEM T lymphoblasts, Raji bone marrow-derived (B) lymphoblasts, and ...

Cytotoxicity of human macrophages for tumor cells. Enhancement by human lymphocyte mediators.

Human macrophages, derived from peripheral blood monocytes, acquire enhanced cytotoxicity for human target cells after incubation in mediator-rich supernates from antigen-stimulated lymphocytes. Maximum cytotoxicity was observed after 24-h incubation in mediators. In comparison to normal macrophages, mediator-activated macrophages were cytotoxic to five of the six malignant cell lines tested bu...

Human pulmonary macrophage tumor cell cytotoxicity.

In vivo animal studies support the concept that monocytes and macrophages are important in the immune surveillance of oncogenesis and in vitro activated murine macrophages are cytocidal for tumor cells. In this study. we examined human pulmonary macrophage and blood monocyte tumor cell cytotoxicity (a measure of cytostasis and cell kill) and cytocidal activity (cell kill). Three human tumor cel...

cytotoxicity of euphorbia bungei on hela and ht29 tumor cells